Phosphorothioation of DNA in bacteria by dnd genes.
نویسندگان
چکیده
Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
منابع مشابه
A Novel Target of IscS in Escherichia coli: Participating in DNA Phosphorothioation
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ورودعنوان ژورنال:
- Nature chemical biology
دوره 3 11 شماره
صفحات -
تاریخ انتشار 2007